Full-Spectrum NGS Microbiome Intelligence

Your microbiome
decoded at the
deepest level.

Shotgun metagenomics with AI-generated dynamic biomarkers — each backed by clinical study references, personalised to your biology. Virome, mycobiome, archaeome, resistome, and functional gene pathways. The only consumer test that shows you what your microbiome is doing, not just who lives there.

BIOS · Sample Report Preview
Alex V.
BIO-2026-04741 · April 14, 2026
Shotgun Metagenomics · 35M reads
70
/100
Mood & Brain
70
Metabolic Health
74
Gut Barrier
66
Immune System
78
Resistome
48
⚡ AI PATTERN DETECTEDOral-gut translocation cluster — 5 co-elevated oral anaerobes. Periodontal evaluation recommended.
💀 SULFUR-REDUCING CONSORTIUMDesulfovibrio piger at 97.3th percentile (42× reference). Primary neuroinflammation driver.
35M+
Reads per sample
11
Report categories
100K+
Microbial species
CLIA
Certified lab
Process

From sample to intelligence
in 10 days.

A simple at-home collection. Lab-grade analysis. A report that tells you what to do about it.

Step 01
📦
Order & Collect
Your kit arrives within 3 days. Collection takes under 5 minutes using our stool collection system. Stabilisation buffer preserves your sample at room temperature for up to 14 days.
Step 02
🧬
Shotgun Sequencing
Your sample is processed in our CLIA-certified partner lab using Illumina shotgun metagenomics. 35 million reads capture bacteria, viruses, fungi, archaea, and resistance genes simultaneously.
Step 03
🤖
AI Analysis
Our AI pipeline runs HUMAnN3 for functional gene pathways, VirSorter2 for virome, CARD database for resistome, and cross-references your pattern against our growing reference cohort.
Step 04
📊
Your Report
A 35+ page personalised report with clinical references, severity-tiered findings, actionable interventions ranked by evidence, and a longitudinal tracking dashboard for future tests.
AI Interpretation Engine

Biomarkers that adapt
to your biology.

Standard tests apply static reference ranges to everyone. Our AI generates personalised biomarker interpretations drawn from your unique data cross-referenced against clinical literature — updated as the science evolves.

Dynamic · Not Static
Personalised reference ranges
Rather than applying population-average thresholds, our AI contextualises your results against your age, sex, reported symptoms, dietary patterns, and prior test history to generate ranges meaningful to your physiology specifically.
Literature-Grounded
Every biomarker cites its evidence base
Each AI-generated interpretation links directly to peer-reviewed studies. Evidence is tiered — Established (multiple human RCTs), Supported (observational + mechanistic), or Emerging (early-stage science) — so you know exactly how much confidence to place in each finding.
Cross-Pattern AI
Cluster findings invisible as single markers
The most clinically significant findings are patterns — not individual markers. Our AI detects co-occurrence signatures like the oral-gut translocation cluster (5 oral anaerobes simultaneously elevated) that no single biomarker threshold would catch.
AI Biomarker Examples
Live from patient data
Tryptophan Fate Partitioning
Established
Your kynurenine:tryptophan ratio of 1.9× reference suggests inflammatory IDO pathway dominance — a biomarker associated with depression and cognitive impairment in prospective cohort studies.
Myint AM et al. — J Affect Disord 2007 PMID: 17222916
Beta-Glucuronidase Activity
Supported
Your gus cluster reads at 1.6× reference. Elevated beta-glucuronidase deconjugates estrogen in the gut, increasing recirculation — a mechanism linked to hormone-sensitive conditions and inflammatory amplification.
Kwa M et al. — JNCI 2016 PMID: 27382032
Oxalate Degradation Capacity
Supported
oxc/frc gene pool at 0.22× reference indicates low Oxalobacter formigenes equivalence. Combined with dietary oxalate load, this directly predicts joint pain patterns and kidney stone risk as documented in multiple clinical cohorts.
Siener R et al. — Kidney Int 2013 PMID: 23698230
TMAO Production Pathway
Established
cutC/cutD gene abundance elevated above reference. Microbial TMAO production is a well-established independent cardiovascular risk factor — the gut-heart connection validated in the NEJM landmark cohort study.
Tang WH et al. — NEJM 2013 PMID: 23614584
✓
Established
Multiple Human RCTs
Two or more randomised controlled trials in humans confirm the association. Highest confidence tier. Examples: L. reuteri serotonin RCTs, B. longum 1714 stress study, TMAO cardiovascular cohorts.
~
Supported
Observational + Mechanistic
Consistent observational human data plus mechanistic animal or in vitro studies. Moderate confidence. Examples: beta-glucuronidase estrogen recirculation, oxalate degradation and joint pain, H₂S gut barrier disruption.
◎
Emerging
Early-Stage Science
Animal studies or small human pilots with promising but unconfirmed associations. Always disclosed clearly. Examples: vagal tone taxa, sleep architecture microbiome links, quorum sensing in dysbiosis.
Coverage

The only test that covers
all six kingdoms.

Standard 16S tests see about 40% of your microbiome. Biomeshield sees everything — including the domains that matter most for your health and are invisible to every competitor.

🦠
Core
Bacteriome
Species-level resolution of your bacterial community with strain-level identification for clinically relevant organisms. Functional gene pathway output from HUMAnN3 UniRef90 database.
SCFA genesLPS burden Bile acid transform.H₂S genes GABA synthesisTryptophan fate Butyrate capacity
⚡
Exclusive
Virome
Bacteriophage community profiling via VirSorter2. CrAssphage abundance, phage-to-bacteria ratio, lytic vs lysogenic balance. No consumer test currently reports this data.
CrAssphagePhage:bacteria ratio Lytic/lysogenicNovel phage
🍄
Exclusive
Mycobiome
Fungal community via ITS co-extraction. Candida species ratios, Saccharomyces presence, fungi-to-bacteria ratio. Candida parapsilosis and C. albicans distinguished by clinical profile.
Candida spp.S. cerevisiae MalasseziaFungi:bacteria ratio
🏔️
Exclusive
Archaeome
Methanogen profiling invisible to standard 16S V3-V4 primers. Classifies your fermentation type — hydrogen-dominant vs methane-dominant — with direct SIBO subtyping implications.
M. smithiiFermentation type SIBO subtypeTransit time proxy
💊
Exclusive
Resistome
Full antibiotic resistance gene (ARG) profiling via CARD database. Tetracycline, macrolide, beta-lactam, vancomycin, and carbapenem resistance genes quantified. Post-antibiotic recovery tracking.
tetW / tetMermB blaOXAvanANDM-1
🔬
Core
Pathogen Surveillance
Dynamic detection of 200+ pathobionts at species and strain level, referenced against population percentiles. AI co-occurrence pattern detection flags cluster findings invisible as single markers.
Percentile rankedFold-excess Clinical referencesPMIDs Cluster detection
Sample Report

Not a score.
A clinical narrative.

Every finding is personalised to your actual abundance values, referenced to population percentiles, and explained in plain language with the science behind it.

🎯
Personalised to your data
Abundance values, fold-excesses, and percentile ranks pulled directly from your NGS output. No template language — every sentence is specific to your results.
🧠
AI cross-pattern detection
Our AI identifies co-occurrence patterns invisible as single markers — like the oral-gut translocation cluster that appears when 5 oral anaerobes are simultaneously elevated in the gut.
📚
Clinical references with PMIDs
Every finding cites peer-reviewed literature. PMIDs are provided so you and your practitioner can verify the evidence base directly.
📈
Test-over-test tracking
Every marker tracked longitudinally. See your trajectory, measure intervention impact, and watch your microbiome respond to dietary and supplemental changes.
BIOMESHIELD · NGS Report
April 21, 2026
Category scores — tap to expand
100
70
Mood & Brain
100
42
Tryptophan Fate
100
74
Metabolic
100
66
Gut Barrier
100
48
Resistome
100
80
Archaeome
Critical pathogen findings
Fusobacterium mortiferum
700× reference · CRC association
99.8th pct
Desulfovibrio piger
42× reference · H₂S driver
97.3th pct
Finegoldia magna
182× reference · immune evasion
99.9th pct
The Science

Built on the same
infrastructure as
research labs.

We white-label CLIA-certified shotgun metagenomics and run it through open-source validated bioinformatics pipelines — the same tools used in peer-reviewed microbiome research.

35M
Reads per sample — 10× more than standard 16S
99.9%
Species-level taxonomic classification accuracy
6
Biological kingdoms profiled per sample
200+
Pathobionts tracked with population percentiles
Analysis Pipeline
1
DNA Extraction & Sequencing
ZymoBIOMICS protocol for low-bias extraction. Illumina NovaSeq 6000 paired-end sequencing. 35M reads standard; 70M reads for Elite tier.
2
Taxonomic Classification
QIIME2 + DADA2 for 16S compatibility reference. Kraken2 + Bracken for shotgun species-level classification against SILVA 138 and RefSeq databases.
3
Functional Gene Profiling
HUMAnN3 against UniRef90 for metabolic pathway reconstruction. SCFA gene families, tryptophan fate partitioning, GABA synthesis genes, bile acid transformation capacity.
4
Virome / Mycobiome / Resistome
VirSorter2 for phage detection. ITS2 co-extraction for fungi. CARD database v3.2 for ARG profiling. All six kingdoms from a single stool sample.
5
AI Report Generation
Cross-pattern detection across all categories. Population percentile ranking against our reference cohort. Personalised narrative generation with evidence-tiered intervention recommendations.
Comparison

How Biomeshield compares
to the alternatives.

Most consumer tests use 16S amplicon sequencing — a 30-year-old technology that misses fungi, viruses, archaea, and resistance genes entirely. None generate AI-personalised dynamic biomarkers with clinical study references.

Feature Biomeshield Viome Microba Thorne/Onegevity Biomesight Ombre / Floré
Sequencing method Shotgun metagenomics Metatranscriptomics Shotgun metagenomics Shotgun metagenomics 16S amplicon 16S amplicon
Species-level resolution ✓ ✓ ✓ Partial ✗ Genus only ✗ Genus only
Functional gene pathways ✓ HUMAnN3 ✓ RNA-based Limited Limited ✗ ✗
AI dynamic biomarkers ✓ Personalised Proprietary scores ✗ ✗ ✗ ✗
Clinical references (PMIDs) ✓ Every finding ✗ Some ✗ Some ✗
Virome profiling ✓ VirSorter2 ✗ ✗ ✗ ✗ ✗
Mycobiome (fungi) ✓ ITS co-extraction ✗ ✗ ✗ ✗ ✗
Archaeome / methanogens ✓ ✗ Partial ✗ ✗ ✗
Resistome / ARG profiling ✓ CARD database ✗ ✗ ✗ ✗ ✗
Pathogen percentile ranking ✓ 200+ organisms Limited Limited Limited Basic ✗
AI co-occurrence patterns ✓ ✗ ✗ ✗ ✗ ✗
Longitudinal tracking ✓ ✓ ✓ Limited ✓ Basic
Price From $199 $149–$299 ~$180 AUD $248+ £149–£199 $99–$149
Pricing

One test. Three depths
of intelligence.

All tiers use the same CLIA-certified shotgun metagenomics. The difference is sequencing depth, category coverage, and consultation access.

Essential
Core NGS
$199 / test
Full shotgun metagenomics with bacteriome, basic functional pathways, and pathogen surveillance. Perfect for a first look at your microbiome at NGS depth.
  • 35M reads — Illumina NovaSeq
  • Bacteriome — species-level resolution
  • Functional gene pathways (core)
  • Pathogen percentile ranking — 200+ organisms
  • AI pattern detection
  • Clinical references with PMIDs
  • Tryptophan fate partitioning
  • Digital report — 25+ pages
  • Longitudinal tracking dashboard
Complete
Full Spectrum
$349 / test
The complete six-kingdom analysis. Everything in Core plus virome, mycobiome, archaeome, and resistome. The most comprehensive consumer microbiome test available.
  • 35M reads — Illumina NovaSeq
  • All Core NGS features
  • Virome — VirSorter2 phage profiling
  • Mycobiome — ITS fungal community
  • Archaeome — fermentation type classification
  • Resistome — full ARG profiling (CARD)
  • Strain-level resolution for key species
  • 35+ page report with all 11 categories
  • 30-min practitioner consultation included
Research
Elite
$549 / test
Deep sequencing for maximum resolution. 70M reads, metatranscriptomics add-on available, and a 60-min consultation with a microbiome specialist.
  • 70M reads — ultra-deep sequencing
  • All Full Spectrum features
  • Strain-level SNP resolution
  • Metatranscriptomics add-on available
  • 60-min specialist consultation
  • Raw FASTQ data access
  • Quarterly retest program available
  • Priority 7-day turnaround
  • Dedicated case manager

All tests include free shipping both ways · Results in 10–14 days · CLIA-certified lab

Reviews

What our members discovered.

Real findings from real tests. These aren't marketing claims — they're what happens when you actually sequence the full microbiome.

★★★★★
I'd been told my gut was "normal" by two other tests. Biomeshield found Helicobacter cinaedi at the 99.9th percentile — an organism my gastroenterologist had never looked for. It explained symptoms I'd had for three years.
Michael R., 44
Functional medicine patient · New York
★★★★★
The tryptophan fate partitioning changed how I think about my depression. Seeing that 58% of my tryptophan was going down the kynurenine route — with the research to back it up — gave me something concrete to work with my psychiatrist on.
Sarah K., 36
Integrative health practitioner · Austin
★★★★★
The resistome findings were worth the test alone. After two courses of antibiotics last year, seeing my tetracycline resistance gene load and understanding the recovery protocol was exactly what I needed. Three months later the retest shows real improvement.
David L., 51
Biohacker · San Francisco
Questions

Frequently asked questions.

Everything you need to know before ordering.

How is shotgun different from 16S?
16S amplicon sequencing targets a single bacterial gene region — it misses fungi, viruses, archaea, and resistance genes entirely, and only reaches genus-level resolution. Shotgun metagenomics sequences all DNA in your sample, capturing everything across all kingdoms at species and strain level, plus functional gene output.
Does elevated abundance mean I have an infection?
No. Elevated abundance means an organism is present at higher levels than population norms — not that you have an active infection. Our report explains the spectrum from commensal to opportunistic to pathogenic, and recommends clinical follow-up only where warranted. This is a surveillance and optimisation tool, not a diagnostic device.
How long does it take to get results?
Standard turnaround is 10–14 days from sample receipt at the lab. Elite tier has a priority 7-day turnaround. You'll receive an email notification when your report is ready, with a link to your secure dashboard.
Is the test available outside the US?
Currently available in the United States and Canada. UK and EU availability coming Q3 2026. International shipping for research purposes may be available — contact us directly.
Can I share results with my doctor?
Yes — and we encourage it. Every finding includes clinical references with PMIDs so your physician can review the evidence base. Your report is downloadable as a print-ready PDF. We also offer practitioner portal access for clinicians who work with multiple patients.
How is my data handled?
Your raw sequencing data is stored encrypted and never sold. De-identified data may be used to improve our population reference cohort — you can opt out at any time. We are HIPAA compliant and use SOC 2 Type II certified infrastructure.
What do I need to do before collecting?
Avoid antibiotics for 4 weeks before collection if possible. No dietary restrictions required. Collect any time of day. Do not collect during or immediately after a gastrointestinal illness. Full instructions are included with your kit.
How often should I retest?
We recommend retesting every 8–12 weeks if you are actively working on intervention targets identified in your report. Annual testing is sufficient for ongoing surveillance if your results are in a healthy range. Longitudinal tracking becomes more valuable with each test.
Get Started

Your microbiome holds
answers medicine
hasn't found yet.

Most diseases have a microbiome signature that appears years before symptoms. Biomeshield gives you the resolution to see it — and the knowledge to act on it.

Free shipping both ways · Results in 10–14 days · CLIA-certified lab · 100% satisfaction guarantee